Hendrix College

Duina, Andrea

Andrea Duina Ph. D.

Associate Professor of Biology

duina@hendrix.edu DW Reynolds Room 422 (501) 450-4536 (501) 450-4547

Biology Professor Awarded NSF Grant

Dr. Andrea Duina receives $415,515 National Science Foundation grant

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Faculty Faces – Dr. Andrea Duina

In life and in the lab, cell biologist seeks interesting places to learn and grow

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Duina receives NSF Grant

$473,089 award supports research at Hendrix

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Academic Background

  • Postdoc, Harvard Medical School, 1998-2004
  • Ph.D., Northwestern University, 1998
  • B.S., University of Illinois-Champaign, 1992

Research Interests

  • We use the budding yeast Saccharomyces cerevisiae to gain insights into the process of eukaryotic gene transcription.  We are particularly interested in the functional and physical interactions that occur between the histone chaperone complex yFACT and chromatin during active transcription.

Scientific Publications

  • Duina, A.A., Miller M.E. and J.B. Keeney.  2014.  Budding yeast for budding geneticists: a primer on the Saccharomyces cerevisiae model system.  Genetics 197, 33-48.
  • Nguyen H.-T.T., Wharton W. II, Harper J.A., Dornhoffer J.R., and A.A. Duina.  2013.  A nucleosomal region important for ensuring proper interactions between the transcription elongation factor Spt16 and transcribed genes in Saccharomyces cerevisiae.  G3: Genes, Genomes, Genetics 3, 929-940.
  • A.A. Duina.  2013.  New roles for old characters:  an Educational Primer for use with “Vps factors are required for efficient transcription elongation in budding yeast”.  Genetics 194, 27-33.
  • A.A. Duina.  2011.  Histone Chaperones Spt6 and FACT:  similarities and differences in modes of action at transcribed genes. Genet. Res. Int. (Special issue: Gene Control During Transcription Regulation),   2011, Article ID 625210.
  • Myers C.N., Berner G.B., Holthoff J.H., Martinez-Fonts K., Harper J.A., Alford S., Taylor M.N., and A.A. Duina. 2011. Mutant Versions of the S. cerevisiae transcription elongation factor Spt16 define regions of Spt16 that functionally interact with histone H3. PLoS ONE 6, e20847.
  • Lloyd, A, K. Pratt, E. Siebrasse, M.D. Moran and A.A. Duina. 2009. Uncoupling of the patterns of chromatin association of different transcription elongation factors by a histone H3 mutant in Saccharomyces cerevisiae. Eukaryot. Cell 8, 257-260.
  • Duina, A.A., A. Rufiange, J. Bracey, J. Hall, A. Nourani and F. Winston. 2007. Evidence that the localization of the elongation factor Spt16 across transcribed genes is dependent upon histone H3 integrity in Saccharomyces cerevisiae. Genetics 177, 101-112.
  • Duina, A.A. and F. Winston. 2004. Analysis of a mutant histone H3 that perturbs the association of Swi/Snf with chromatin. Mol. Cell. Biol. 24, 561-572.
  • Duina, A.A., H.M. Kalton, and R.F. Gaber. 1998. Requirement for Hsp90 and a CyP-40-type cyclophilin in negative regulation of the heat shock response. J. Biol. Chem. 273,18974-18978. 
  • Duina, A.A., J.A. Marsh, R.B. Kurtz, J.H.-C. Chang, S. Lindquist, and R.F. Gaber. 1998. The peptidyl-prolyl isomerase domain of the CyP-40 cyclophilin homolog Cpr7 is not required to support growth or glucocorticoid receptor activity in Saccharomyces cerevisiae. J. Biol. Chem. 273, 10819-10822. 
  • Duina, A.A., J.H.-C. Chang, J.A. Marsh, S. Lindquist, and R.F. Gaber. 1996. A cyclophilin function in Hsp90-dependent signal transduction. Science 274, 1713-1715. 
  • Duina, A.A., J.A. Marsh, and R.F. Gaber. 1996. Identification of two CyP-40-like cyclophilins in Saccharomyces cerevisiae, one of which is required for normal growth. Yeast 12, 943-952.

Other Publications

  • Duina, A.A. 2007. Listen to your calling. ASBMB Today (February 2007), 19-20.

Recent Research Grants

  • National Science Foundation, RUI Continuing Grant (2013-2016): "Studies on the Interactions Between the yFACT and TORC1 Complexes and Chromatin During transcription Elongation"
  • National Science Foundation, RUI Continuing Grant (2009-2012): "Investigation of the mechanisms that regulate interactions between the transcription elongation factor Spt16 and chromatin"
  • National Science Foundation, RUI Continuing Grant (2006-2010): "Analysis of the role of histone H3 in transcription elongation"

Recent Scientific Conferences; Organizer or Chair of Platform Session

  • Platform Session Chair: 18th Annual Southeastern Regional Yeast Meeting.  Mississippi State University, Mississippi State, MS.  March 11-13, 2011.
  • Co-organizer:  17th Annual Southeastern Regional Yeast Meeting.  William J. Clinton Presidential Center, Little Rock, AR.  March 12-14, 2010.  

Invited Seminars

  • Rhodes College - Department of Biology. October 23, 2013.  Breaking chromatin to understand it: a genetic approach provides new insights into the transcription elongation process.
  • Arkansas INBRE Research Conference - Invited Speaker. October 18, 2013.  Identification of a Nucleosomal Region Important for Ensuring Proper Interactions between the Transcription Elongation Factor Spt 16 and Transcribed Genes in Budding Yeast.
  • Emory University School of Medicine - Department of Biochemistry, February 23, 2012.  Analysis of yeast cells expressing specific histone mutants provide new insights into the process of transcription elongation.
  • Louisiana State University Health Science Center, School of Medicine in Shreveport - Department of Biochemistry and Molecular Biology, January 20, 2011. Insights into the process of transcription elongation through the analysis of histone mutants in yeast.
  • University of Arkansas at Little Rock - Department of Applied Sciences, November 15, 2010.  Insights into the process of transcription elongation through the analysis of histone mutants in yeast.
  • University of Arkansas for Medical Sciences - Department of Biochemistry and Molecular Biology, September 15, 2010. New insights into the process of transcription elongation in yeast.
  • University of Iowa - Department of Biochemistry, December 11, 2008.  Insights into the mechanism of yFACT association across transcribed genes in vivo.
  • University of Central Arkansas - Department of Biology, February 18, 2008.  A role for histone H3 in ensuring proper distribution of the elongation complex yFACT across transcribed genes.
  • University of Arkansas at Fayetteville - Department of Biology, November 8, 2007. A role for histone H3 in ensuring proper distribution of the elongation complex yFACT across transcribed genes.
  • Rhodes College - Department of Biology, November 13, 2006. A dysfunctional relationship: when a transcription factor just can't let go. 
  • University of Arkansas for Medical Sciences - Department of Physiology, September, 2005. Evidence that the localization of the elongation factor Spt16 across transcribed genes is dependent upon histone H3 integrity in yeast. 

Current Members of the Lab

  • Brandon Cox (Undergraduate Student)
  • Martha Kellems (Undergraduate Student)
  • Sarah Marshall (Laboratory Technician)
  • Taylor McElroy (Undergraduate Student)
  • Ginny Mitchell (Undergraduate Student)